Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. A central mechanism of action for paracetamol has been proposed,14. On average, paracetamol is a weaker analgesic drug when compared to nsaids or the selective cox2 inhibitors. Paracetamol, if efficient, is a recommended oral analgesic of a first choice to be used for a long time, e.
Use the pharmacophoto video flashcard series to reinforce your knowledge of drug classes and specific medications. The apparent cox2 selectivity of action of paracetamol is shown by its poor antiplatelet activity and good gastrointestinal tolerance. Paracetamol concentrations in the cerebrospinal fluid mirror response to fever and pain to a greater extent than plasma concentrations. However, the in vivo effects of paracetamol are similar to those of the selective cyclooxygenase2 cox2 inhibitors. Paracetamol often appears to have cox2 selectivity. Whilst its clinical significance may be equivocal, paracetamol may exert effects on virtually every organ system, warranting further research. Acetaminophen nursing considerations, side effects and. Mechanism of action,method of toxicity,metabolism,stages of toxicity,treatment,side effect slideshare uses cookies to improve functionality and performance, and to.
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